GMPify Regulation Library

Pharmaceutical GMP Regulations, Explained

Plain-language explanations of the FDA, EU GMP and ICH provisions that matter most, what they require, what inspectors look for, and the most common violation pattern for each. Built from the same primary-source approach as every GMPify course.

US FDA
21 CFR 211.192

Production Record Review - Investigation of Discrepancies and Failures

21 CFR 211.22(d)

Quality Control Unit Responsibilities and Independence

21 CFR 211.100(a)

Written Procedures - Establishment and Adherence

21 CFR 211.160(b)

Laboratory Controls - Scientifically Sound Specifications and Methods

21 CFR 211.198

Complaint Files

21 CFR 314.81(b)(1)

Field Alert Report Requirements

21 CFR 211.63

Equipment Design, Size and Location

21 CFR 211.65

Equipment Construction - Contact Surfaces

21 CFR 211.68

Automatic, Mechanical and Electronic Equipment

21 CFR 211.84

Testing and Approval or Rejection of Components

21 CFR 211.113

Control of Microbiological Contamination

21 CFR 211.165

Testing and Release for Distribution

21 CFR 211.188

Batch Production and Control Records

21 CFR 211.180

General Requirements - Records Retention and Annual Review

21 CFR 211.42

Design and Construction Features of Buildings and Facilities

21 CFR 211.67

Equipment Cleaning and Maintenance

21 CFR 211.166

Stability Testing

21 CFR 211.194

Laboratory Records

21 CFR 820.100

Corrective and Preventive Action (QMSR)

21 CFR 211.25

Personnel Qualifications

21 CFR 211.34

Consultants

21 CFR 211.94

Drug Product Containers and Closures

21 CFR 211.122

Labeling Issuance and Control

21 CFR 211.125

Labeling Reconciliation

21 CFR 211.130

Packaging and Label Operations

21 CFR 211.150

Distribution Procedures

21 CFR 211.170

Reserve Samples

21 CFR 211.204

Returned Drug Products

21 CFR 211.208

Drug Product Salvaging

21 CFR 211.46

Ventilation, Air Filtration, Air Heating and Cooling

21 CFR 211.48

Plumbing

21 CFR 211.72

Filters

21 CFR 211.80

General Requirements - Component and Container Receipt

21 CFR 211.87

Retesting of Approved Components, Containers and Closures

21 CFR 211.142

Warehousing Procedures

21 CFR 211.182

Equipment Cleaning and Use Log

21 CFR Part 11

Electronic Records and Electronic Signatures

21 CFR 211.28

Personnel Responsibilities - Gowning and Health

21 CFR 211.56

Sanitation

21 CFR 211.58

Maintenance

21 CFR 211.103

Calculation of Yield

21 CFR 211.115

Reprocessing

21 CFR 211.137

Expiration Dating

21 CFR 211.101

Charge-in of Components

21 CFR 211.105

Equipment Identification

21 CFR 211.134

Drug Product Inspection

21 CFR 210.3

Definitions

21 CFR 820.30

Design Controls (QMSR)

21 CFR 820.90

Nonconforming Product (QMSR)

21 CFR 820.184

Device History Record (QMSR)

21 CFR 820.198

Complaint Files (QMSR)

21 CFR 820.75

Process Validation (QMSR)

21 CFR 820.50

Purchasing Controls (QMSR)

FD&C Act Section 501

Adulteration

FD&C Act Section 502

Misbranding

21 CFR 211.1

Scope of 21 CFR Part 211

21 CFR 820.40

Document Controls (QMSR)

21 CFR 820.181

Device Master Record (QMSR)

21 CFR 211.176

Penicillin Contamination

FD&C Act Section 505

New Drug Approval

EU GMP
EU GMP Annex 1, Section 9

Environmental and Process Monitoring - Aseptic Processing

EU GMP Annex 15

Qualification and Validation

EU GMP Chapter 8

Complaints, Quality Defects and Product Recalls

EU GMP Chapter 1

Pharmaceutical Quality System

EU GMP Annex 11

Computerised Systems

EU GMP Annex 16

Certification by a Qualified Person and Batch Release

EU GMP Annex 13

Investigational Medicinal Products

EU GMP Annex 19

Reference and Retention Samples

EU GMP Annex 17

Real Time Release Testing and Parametric Release

EU GMP Chapter 3

Premises and Equipment

EU GMP Chapter 6

Quality Control

EU GMP Chapter 4

Documentation

EU GMP Chapter 5

Production

EU GMP Annex 21

Importation of Medicinal Products

ICH Guidelines
ICH Q9(R1)

Quality Risk Management

ICH Q2(R2)

Validation of Analytical Procedures

ICH Q10

Pharmaceutical Quality System

ICH Q1A(R2)

Stability Testing of New Drug Substances and Products

ICH Q7

Good Manufacturing Practice for Active Pharmaceutical Ingredients

ICH Q12

Technical and Regulatory Considerations for Pharmaceutical Product Lifecycle Management

ICH Q8(R2)

Pharmaceutical Development

ICH Q3B(R2)

Impurities in New Drug Products

ICH Q5C

Quality of Biotechnological Products - Stability Testing

ICH Q3A(R2)

Impurities in New Drug Substances

ICH Q3C(R9)

Residual Solvents

ICH Q3D(R2)

Elemental Impurities

ICH Q11

Development and Manufacture of Drug Substances

ICH E6(R3)

Good Clinical Practice

USP General Chapters
USP <71>

Sterility Tests

USP <1116>

Microbiological Control and Monitoring of Aseptic Processing Environments

USP <1058>

Analytical Instrument Qualification

USP <1225>

Validation of Compendial Procedures

USP <85>

Bacterial Endotoxins Test

USP <61>

Microbiological Examination of Nonsterile Products - Microbial Enumeration Tests

USP <62>

Microbiological Examination of Nonsterile Products - Tests for Specified Microorganisms

USP <232> and <233>

Elemental Impurities - Limits and Procedures

USP <1231>

Water for Pharmaceutical Purposes

USP <797>

Pharmaceutical Compounding - Sterile Preparations

USP <800>

Hazardous Drugs - Handling in Healthcare Settings

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